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. 2022 Feb 23;12:844613. doi: 10.3389/fonc.2022.844613

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Copyright © 2022 Yang, Chen, Qian, Zhang, Wu and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The relative mRNA expression level of METTL3 in EOC and OE groups. (B) The relative mRNA expression level of KRT8 in EOC and OE groups. (C) Real-time PCR analysis and western blot analysis for METTL3 expression in COV362 untreated cells (Control), cells transfected with empty vector (Vector), and cells transfected with METTL3-siRNA (METTL3-siRNA). (D) MTT assay showing cell viability of Control, Vector and METTL3-siRNA cells. (E) The TUNEL assay showing the apoptosis rates of Control, Vector and METTL3-siRNA cells. (F) Cell cycle analysis of Control, Vector and METTL3-siRNA cells. (G) Western blot showing the expression levels of KRT8 and FAS in Control, Vector and METTL3-siRNA cells. * P < 0.05, ** Compared with the other groups, P < 0.01.