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. 2022 Mar 8;12:3771. doi: 10.1038/s41598-022-07674-7

Table 2.

Multi-component synthesis of 1,2,3‐triazole derivatives at 65 °C temperature using water as solvent and Fe3O4@Pectin@(CH2)3-Acetamide-Cu(II) as catalyst.

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Entry R1 R2 X Products Time (min) Yielda (%) TON TOF
1 Ph-CH2 Ph Cl 4a 120 97 194 97
2 4-Me-Ph-CH2 Ph Cl 4b 125 95 188 90.25
3 4-Cl-Ph-CH2 Ph Cl 4c 130 93 188 87.03
4 2-Cl-Ph-CH2 Ph Cl 4d 135 92 184 81.77
5 Ph-CH2 Me2C–OH Cl 4e 140 94 188 80.68
6 4-Me-Ph-CH2 Me2C–OH Cl 4f. 140 93 186 79.82
7 4-Cl-Ph-CH2 Me2C–OH Cl 4 g 120 95 190 95
8 2-Cl-Ph-CH2 Me2C–OH Cl 4 h 130 96 192 87.27
9 Phenacyl Ph Br 4i 90 98 196 130.66
10 4-Br-Phenacyl Ph Br 4j 90 91 182 121.33
11 4-NO2-Phenacyl Ph Br 4 k 90 90 180 120
12 Phenacyl Me2C–OH Br 4 l 100 90 180 108.43
13 4-Br-Phenacyl Me2C–OH Br 4 m 100 87 174 104.81
14 4-NO2-Phenacyl Me2C–OH Br 4n 100 87 174 104.81
15 Phenacyl CH2OH Br 4o 100 92 184 110.84
16 4-Br-Phenacyl CH2OH Br 4p 100 89 178 107.23

Alkyl halides (1.0 mmol), Sodium azide (1.2 mmol), alkyne (1.0 mmol), catalyst (0.5 mol %) were placed in a test tube on a stirrer at 65 °C for 120 min under H2O (2 ml) as a solvent.

aYields of isolated product.