Table 2.
Multi-component synthesis of 1,2,3‐triazole derivatives at 65 °C temperature using water as solvent and Fe3O4@Pectin@(CH2)3-Acetamide-Cu(II) as catalyst.
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Entry | R1 | R2 | X | Products | Time (min) | Yielda (%) | TON | TOF |
1 | Ph-CH2 | Ph | Cl | 4a | 120 | 97 | 194 | 97 |
2 | 4-Me-Ph-CH2 | Ph | Cl | 4b | 125 | 95 | 188 | 90.25 |
3 | 4-Cl-Ph-CH2 | Ph | Cl | 4c | 130 | 93 | 188 | 87.03 |
4 | 2-Cl-Ph-CH2 | Ph | Cl | 4d | 135 | 92 | 184 | 81.77 |
5 | Ph-CH2 | Me2C–OH | Cl | 4e | 140 | 94 | 188 | 80.68 |
6 | 4-Me-Ph-CH2 | Me2C–OH | Cl | 4f. | 140 | 93 | 186 | 79.82 |
7 | 4-Cl-Ph-CH2 | Me2C–OH | Cl | 4 g | 120 | 95 | 190 | 95 |
8 | 2-Cl-Ph-CH2 | Me2C–OH | Cl | 4 h | 130 | 96 | 192 | 87.27 |
9 | Phenacyl | Ph | Br | 4i | 90 | 98 | 196 | 130.66 |
10 | 4-Br-Phenacyl | Ph | Br | 4j | 90 | 91 | 182 | 121.33 |
11 | 4-NO2-Phenacyl | Ph | Br | 4 k | 90 | 90 | 180 | 120 |
12 | Phenacyl | Me2C–OH | Br | 4 l | 100 | 90 | 180 | 108.43 |
13 | 4-Br-Phenacyl | Me2C–OH | Br | 4 m | 100 | 87 | 174 | 104.81 |
14 | 4-NO2-Phenacyl | Me2C–OH | Br | 4n | 100 | 87 | 174 | 104.81 |
15 | Phenacyl | CH2OH | Br | 4o | 100 | 92 | 184 | 110.84 |
16 | 4-Br-Phenacyl | CH2OH | Br | 4p | 100 | 89 | 178 | 107.23 |
Alkyl halides (1.0 mmol), Sodium azide (1.2 mmol), alkyne (1.0 mmol), catalyst (0.5 mol %) were placed in a test tube on a stirrer at 65 °C for 120 min under H2O (2 ml) as a solvent.
aYields of isolated product.