Table 3.
Risk factors for slower progression to AIDSAD in Chinese patients.
| Number of sequences | AIDSAD prevalencea | Univariable analysisb | Multivariable analysisc | |||
|---|---|---|---|---|---|---|
| OR(95% CI) | P value | OR(95% CI) | P value | |||
| Sex | ||||||
| Men | 9681 | 2210(22.83) | Reference | |||
| Women | 758 | 210(27.7) | 1.29(1.1–1.53) | 0.002 | 0.86(0.71–1.04) | 0.12 |
| Age at diagnosis(years) group | ||||||
| < 18 | 48 | 10(20.83) | Reference | |||
| 18–24 | 1625 | 207(12.74) | 0.55(0.12–1.19) | 0.1 | 1.11(0.48–2.94) | 0.82 |
| 25–44 | 6559 | 1463(22.31) | 1.09(0.28–2.32) | 0.81 | 2.05(0.9–5.4) | 0.11 |
| 45–64 | 1962 | 648(33.03) | 1.87(0.56–4) | 0.08 | 3.36(1.47–8.87) | 0.007 |
| ≥ 65 | 240 | 91(37.92) | 2.32(1.14–5.13) | 0.03 | 4.32(1.81–11.75) | 0.002 |
| Ethnicity | ||||||
| Han | 9879 | 2310(23.38) | Reference | |||
| Uyghur | 97 | 8(8.25) | 0.29(0.13–0.57) | < 0.001 | 0.49(0.21–1.02) | 0.08 |
| Yi | 90 | 7(7.78) | 0.28(0.12–0.56) | 0.001 | 0.43(0.17–0.9) | 0.04 |
| Other | 373 | 95(25.47) | 1.12(0.88–1.41) | 0.35 | 1.18(0.92–1.5) | 0.19 |
| Transmission risk group | ||||||
| Heterosexual | 2855 | 841(29.46) | Reference | |||
| MSM | 7086 | 1454(20.52) | 0.62(0.56–0.68) | < 0.001 | 0.67(0.6–0.75) | < 0.001 |
| Injecting drug user | 312 | 51(16.35) | 0.47(0.34–0.63) | < 0.001 | 0.85(0.59–1.2) | 0.36 |
| Blood transfusion | 112 | 51(45.54) | 2(1.36–2.93) | < 0.001 | 1.86(1.24–2.79) | 0.003 |
| Mother to child | 10 | 4(40) | 1.6(0.41–5.6) | 0.47 | 3.36(0.7–15.3) | 0.12 |
| Subtype | ||||||
| B | 1508 | 452(29.97) | Reference | |||
| C | 72 | 20(27.78) | 0.9(0.51–1.5) | 0.69 | 0.82(0.47–1.39) | 0.48 |
| 01_AE | 4819 | 1259(26.13) | 0.83(0.73–0.94) | 0.003 | 0.94(0.82–1.07) | 0.35 |
| 07_BC | 2815 | 421(14.96) | 0.41(0.35–0.48) | < 0.001 | 0.46(0.39–0.53) | < 0.001 |
| 08_BC | 95 | 29(30.53) | 1.03(0.65–1.59) | 0.91 | 0.83(0.51–1.3) | 0.42 |
| 55_01B | 169 | 41(24.26) | 0.75(0.51–1.07) | 0.12 | 0.78(0.53–1.13) | 0.2 |
| URF | 708 | 142(20.06) | 0.59(0.47–0.72) | < 0.001 | 0.62(0.5–0.78) | < 0.001 |
| Minor | 253 | 56(22.13) | 0.66(0.48–0.91) | 0.01 | 0.63(0.45–0.86) | 0.005 |
| Region | ||||||
| North | 5061 | 1191(23.53) | Reference | |||
| North-east | 1486 | 338(22.75) | 0.96(0.83–1.1) | 0.53 | ||
| East | 1251 | 293(23.42) | 0.99(0.86–1.15) | 0.93 | ||
| Central-south | 1324 | 313(23.64) | 1(0.87–1.16) | 0.93 | ||
| South-west | 752 | 168(22.34) | 0.93(0.78–1.12) | 0.47 | ||
| North-west | 542 | 110(20.3) | 0.83(0.66–1.03) | 0.09 | ||
| Sampling phase | ||||||
| 1994–2005 | 71 | 20(28.17) | Reference | |||
| 2006–2008 | 574 | 133(23.17) | 0.77(0.45–1.36) | 0.35 | ||
| 2009–2011 | 1537 | 372(24.2) | 0.81(0.49–1.41) | 0.45 | ||
| 2012–2014 | 2562 | 516(20.14) | 0.64(0.39–1.11) | 0.1 | ||
| 2015–2017 | 3101 | 735(23.7) | 0.79(0.48–1.37) | 0.38 | ||
| 2018–2020 | 2594 | 644(24.83) | 0.84(0.51–1.45) | 0.52 | ||
AIDSAD, AIDS at diagnose; OR, odds ratio; MSM, men who have sex with men; URF, unique recombinant form;
North, Beijing, Tianjin, Hebei, Shanxi, and Inner Mongolia. North-east, Liaoning, Jilin, and Heilongjiang. East, Shanghai, Jiangsu, Zhejiang, Anhui, Fujian, Jiangxi, and Shandong. Central- south, Henan, Hubei, Hunan, Guangdong, Guangxi, and Hainan. South-west, Chongqing, Sichuan, Guizhou, Yunnan, and Tibet. North-west, Shann'xi, Gansu, Qinghai, Ningxia, and Sinkiang.
Minor, A1, D, F1, G, H, CRF02_AG, CRF03_AB, CRF06_cpx, CRF15_01B, CRF18_cpx, CRF24_BG, CRF33_01B, CRF55_01B, CRF57_BC, CRF58_01B, CRF59_01B, CRF61_BC, CRF62_BC, CRF63_02A1, CRF64_BC, CRF65_cpx, CRF67_01B, CRF68_01B, CRF78_cpx, CRF79_0107, CRF82_cpx, CRF83_cpx, CRF85_BC, CRF86_BC, CRF87_cpx, CRF88_BC, and CRF96_cpx.
aData are n(%).
bUnivariable logistic regression analysis.
cMultivariable logistic regression analysis.