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. 2022 Mar 8;5:213. doi: 10.1038/s42003-022-03117-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Average β value distributions of Global, RFS, and CR profiles and region-specific subsets. Semi-supervised hierarchical clustering of the Global profile (b, c), RFS profile (d, e), and CR profile (f, g) in the JNNCRI (left) and NY (right) datasets. CpG sites displaying concordant hypo/hyper-methylation patterns between the independent 450k array datasets are annotated in the first two row annotation tracks of each heatmap. Detailed concordance and differentia methylation results between the cluster groups are presented in Supplementary Table 4.