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. 2022 Mar 8;5:213. doi: 10.1038/s42003-022-03117-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a Violin plots of the average β value distributions of the Global, RFS, and CR profiles and region-specific subsets in the GDSC cell lines and TARGET (for comparison) datasets. Boxplots depict the median, interquartile range (IQR), and 1.5 * IQR. b–d Semi-supervised hierarchical clustering of the 11 OSA cell lines in the GDSC dataset using the Global (b), RFS (c), and CR (d) profiles. CpG sites displaying concordant hypo/hyper-methylation patterns in the cell line GDSC dataset relative to the TARGET clinical dataset are annotated in the first row annotation track of each heatmap. Detailed concordance results are presented in Supplementary Table 6.