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. 2022 Feb 23;9:819621. doi: 10.3389/fmed.2022.819621

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Copyright © 2022 García-Vicuña, Rodriguez-García, Abad-Santos, Bautista Hernández, García-Fraile, Barrios Blandino, Gutiérrez Liarte, Alonso-Pérez, Cardeñoso, Alfranca, Mejía-Abril, Sanz Sanz and González-Alvaro.

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Evolution of partial pressure of arterial oxygen/fraction of inspired oxygen (PaO2/FiO2) throughout study visits. Patients are grouped depending on (A) allocated interventions: standard care (SC) or sarilumab (SAR) and (B) level of serum interleukin-6 (IL-6) at randomization (cut-off for high levels ≥ 30 pg/ml). Two patients died and their last observed value was carried forward. IL-6 levels at randomization were available only in 24 patients; high IL-6 levels were observed in 3 patients from the SAR group and 1 patient from the SC group. Data are shown as interquartile ranges (p75 upper edge of the box, p25 lower edge, p50 midline) as well as the p95 (line above box) and p5 (line below). Dots represent outliers. Statistical significance was determined with the Mann–Whitney U test.