TABLE 1.

Eicosanoid metabolites activating TRP Channels.

Precursor PUFA	Eicosanoid lipid mediator	TPR channel interaction(s)	Reference(s)
Linoleic acid	● 13-hydroxy-9Z,11E-octadecadienoic acid (13-HODE)	TRPA1, TRPV1, TRPV2, agonist	Patwardhan et al., 2009, 2010; De Petrocellis et al., 2012
	● 13-oxo-9Z,11E-octadecadienoic acid (13-oxo-HODE)	TRPV1 agonist	Patwardhan et al., 2009, 2010
	● 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE)	TRPA1, TRPV1 agonist	Patwardhan et al., 2009, 2010; De Petrocellis et al., 2012
	● 9-ox0-10E,12Z-octadecadienoic acid (9-oxo-HODE)	TRPV1 agonist	Patwardhan et al., 2009, 2010
	● 9,10-dihydroxy-12Z-octadecenoic acid (9,10-DiHOME)	TRPA1, TRPV1 agonist	Eskander et al., 2015; Green et al., 2016; Sisignano et al., 2016
	● 9,10-epoxy-12Z-octadecenoic acid (9(10)EpOME)	TRPA1, TRPV1 agonist	Eskander et al., 2015; Green et al., 2016; Sisignano et al., 2016
	● 12,13-dihydroxy-9Z-octadecenoic acid (12,13-DiHOME)	TRPA1, TRPV1 agonist	Eskander et al., 2015; Green et al., 2016; Sisignano et al., 2016; Zimmer et al., 2018
	● 12(13)epoxy-9Z-octadecenoic acid (12(13)EpOME)	TRPA1, TRPV1 agonist	Eskander et al., 2015; Green et al., 2016; Sisignano et al., 2016
Arachidonic acid	● 5,6-epoxy-8Z,11Z,14Z-eicosatrienoic acid (5,6-EET)	TRPA1, TRPV4 agonist	Watanabe et al., 2003; Sisignano et al., 2012
	● 8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid (8,9-EET)	TRPA1, TRPV4 agonist	Watanabe et al., 2003
	● Prostaglandin A1 (PGA1)	TPPA1 agonist	Materazzi et al., 2008
	● Prostaglandin A2 (PGA2)	TPPA1 agonist	Materazzi et al., 2008
	● 8-iso Prostaglandin A2 (8-iso-PGA2)	TRPA1 agonist	Hwang et al., 2000
	● 12S-hydroperoxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HpETE)	TRPV1 agonist	Hwang et al., 2000
	● 15S-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid (15-HpETE)	TRPV1 agonist	Hwang et al., 2000
	● 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-HETE)	TRPV1 agonist	Hwang et al., 2000
	● Leukotriene B4 (LTB4)	TRPV1 agonist	Hwang et al., 2000