Table 3. Prognostic factors in univariate and multivariate analyses for patients with positive tumor markers.

Characteristics	P (univariate)	HR (multivariate)	95% CI (multivariate)	P (multivariate)
Sex	0.797	–	–	–
Age	0.174	–	–	–
ypT stage	P<0.001*	0.378	0.305–0.470	P<0.001*
ypN stage	P<0.001*	4.869	4.135–5.734	P<0.001*
yTNM stage	P<0.001*	1.705	1.371–2.120	P<0.001*
Tumor location	0.963	–	–	–
Differentiated degree	P<0.001*	0.481	0.416–0.558	P<0.001*
Signet-ring cell component	P<0.001*	0.866	0.774–0.970	0.013*
CEA-pre	0.002*	0.872	0.790–0.964	0.007*
CA199-pre	P<0.001*	1.543	1.379–1.726	P<0.001*
CA125-pre	P<0.001*	1.151	1.022–1.295	0.020*
AFP-pre	0.520	–	–	–
CA242-pre	P<0.001*	1.181	1.053–1.325	0.005*
CA724-pre	0.002*	0.954	0.863–1.055	0.359
Number of positive tumor markers before NCT	P<0.001*	1.555	1.312–1.844	P<0.001*
Normalization of tumor markers after NCT	P<0.001*	1.375	1.240–1.525	P<0.001*

*, P<0.05. NCT, neoadjuvant chemotherapy; HR, hazard ratio; CI, confidence interval.