Table 1. Summary of MIC and FICI values of the 8 enterococci strains.
Strains | MIC (mg/L) | MICcombination | FICI | ||||
---|---|---|---|---|---|---|---|
VAN | LNZ | FOS | LNZ/FOS | LNZ + FOS | |||
No. 1 | 4 | 2 | 64 | 0.03125/64 | 1.015 | ||
No. 2 | 4 | 2 | 128 | 0.5/32 | 0.5 | ||
No. 3 | 2 | 2 | 128 | 1/32 | 0.75 | ||
No. 4 | 2 | 4 | 256 | 0.5/128 | 0.625 | ||
No. 5 | 1 | 4 | 128 | 1/32 | 0.5 | ||
No. 8 | 128 | 2 | 128 | 1/32 | 0.75 | ||
ATCC 29212 | 1 | 2 | 128 | 1/64 | 1 | ||
ATCC 51299 | 256 | 2 | 128 | 0.5/32 | 0.5 |
VAN: ≤4 mg/L, susceptible (S); 8–16 mg/L, intermediate (I); ≥32 mg/L, resistant (R). LNZ: ≤2 mg/L, susceptible (S); 4 mg/L, intermediate (I); ≥8 mg/L, resistant I. FOS: ≤64 mg/L, susceptible (S); 128 mg/L, intermediate (I); ≥256 mg/L, resistant (R). MIC, minimum inhibitory concentration; VAN, vancomycin; LNZ, linezolid; FOS, fosfomycin; LNZ + FOS, linezolid-fosfomycin combination; FICI, fractional inhibitory concentration index.