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. 2022 Mar 9;22:113. doi: 10.1186/s12876-022-02188-y

Table 3.

Laboratory characteristics of patients with moderate COVID-19 on admission

Analytes Training set (n = 70) Validation set (n = 31)
All patients Liver function damage group Normal liver function group All patients Liver function damage group Normal liver function group
n M/x¯ n M/x¯ n M/x¯ n M/x¯ n M/x¯ n M/x¯
Liver function parameters
TP 70 69.50 45 69.22* 25 71.25 22 68.71 12 65.58* 10 73.14
ALB 70 40.49 45 38.15* 25 42.00 22 39.55 12 35.94* 10 43.87
ALT 70 25.00 45 31.00* 25 19.00 31 19.70 21 16.00* 10 24.00
AST 70 26.00 45 28.00* 25 21.00 31 22.00 21 22.00 10 23.50
ALP 59 70.73 34 68.32 25 74.00 22 60.87 12 60.51 10 61.30
GGT 70 59.00 45 75.00* 25 19.00 31 68.00 21 70.00* 10 24.50
TBIL 70 9.50 45 8.30* 25 11.40 31 9.60 21 8.00* 10 14.50
Kidney function parameters
Glu 70 6.36 45 6.39 25 6.17 31 6.17 21 6.59 10 5.65
Cr 70 67.35 45 67.21 25 67.61 31 65.69 21 65.00 10 67.14
Ur 70 3.69 45 3.65 25 4.02 31 4.17 21 4.17 10 3.96
CO2-CP 70 24.49 45 23.93* 25 25.48 31 24.37 21 22.83* 10 26.90
UA 54 279.25 32 238.05 22 290.50 15 259.63 11 259.19 4 260.83
RBP 53 31.55 31 28.72* 22 35.5 15 29.64 11 27.91 4 34.41
Platelet parameters
PLT 70 189.50 45 188.00 25 194.00 31 186.84 21 179.10 10 203.10
PDW 70 12.35 45 12.11 25 12.77 31 13.24 21 12.37* 10 15.06
PCT 48 12.48 26 10.94* 22 14.29 27 13.36 17 13.22 10 13.59
MPV 70 10.38 45 10.35 25 10.43 31 9.96 21 10.0 10 9.7
Erythrocyte parameters
RBC 70 4.53 45 4.48 25 4.63 31 4.44 21 4.27* 10 4.81
HCT 70 0.41 45 0.40 25 0.41 31 0.40 21 0.39* 10 0.43
HGB 70 139.05 45 138.24 25 140.52 31 138.07 21 132.90* 10 148.92
MCV 70 89.50 45 89.60 25 89.50 31 90.77 21 90.68 10 90.96
MCH 70 30.50 45 30.50 25 30.50 31 31.14 21 31.13 10 31.16
MCHC 70 342.00 45 342.00 25 341.00 31 343.32 21 343.57 10 342.80
RDW 70 11.95 45 11.90 25 12.10 31 11.9 21 12.08 10 11.69
Leukocyte parameters
WBC 70 5.51 45 5.69 25 5.18 31 5.01 21 5.04 10 4.93
NE# 70 3.31 45 3.40 25 2.60 31 3.19 21 3.16 10 3.25
NE% 70 61.73 45 62.49 25 60.37 31 62.40 21 63.10 10 61.60
LY# 70 1.46 45 1.46 25 1.44 31 1.33 21 1.39 10 1.19
LY% 70 28.01 45 27.80 25 28.40 31 27.30 21 27.60 10 23.95
MO# 70 0.40 45 0.40 25 0.50 31 0.50 21 0.32 10 0.50
MO% 70 9.02 45 8.45* 25 10.06 31 8.42 21 7.58* 10 10.20
Coagulation parameters
APTT 47 32.70 28 32.75 19 32.70 17 35.80 14 35.95 3 33.70
TT 47 15.15 28 15.08 19 15.26 17 15.49 14 15.61 3 14.93
PT 47 13.37 28 13.04* 19 13.86 17 12.64 14 12.46 3 13.47
INR 47 1.03 28 1.02 19 1.05 17 1.04 14 1.04 3 1.03
FBG 47 3.03 28 3.21 19 2.86 17 3.13 14 3.06 3 3.48
Electrolyte parameters
Na 64 139.51 41 139.13 23 140.17 28 139.05 19 139.82 9 137.43
K 64 4.02 41 4.03 23 4.00 28 4.05 19 4.00 9 4.17
Cl 64 102.12 41 101.42* 23 103.35 28 100.58 19 101.04 9 99.61
Ca 48 9.82 28 9.62* 20 10.09 13 9.58 10 9.44 3 9.98
Blood lipid parameters
TG 55 1.16 33 1.19 22 1.15 15 1.01 11 1.05 4 0.97
CHO 55 3.91 33 3.79 22 4.09 15 3.78 11 3.76 4 3.84
HDL-C 55 0.84 33 0.80* 22 0.90 15 0.85 11 0.85 4 0.86
LDL-C 54 2.00 32 1.96 22 2.06 15 1.90 11 1.91 4 1.88
Cardiac markers parameters
hsCRP 52 8.25 31 14.70* 21 6.01 24 11.92 17 20.79 7 6.00
CK 42 78.00 26 90.00 16 72.50 25 66.00 16 65.50 9 67.00
CK-MB 56 13.00 35 14.00 21 12.00 29 12.00 19 13.00 10 12.00
LDH 42 193.00 26 206.00* 16 182.00 25 213.24 16 216.81 9 206.89

TP, Total protein, g/L; ALB, Albumin, g/L; ALT, Alanine aminotransferase, U/L; AST, Aspartate aminotransferase, U/L; ALP, Alkaline phosphatase, U/L; GGT, γ-glutamyl transpeptidase, U/L; TBIL, Total bilirubin, μmol/L; Glu, Glucose, mol/L; Cr, Creatinine, μmol/L; Ur, Urea, mmol/L; CO2-CP, Carbon dioxide combining power, mmol/L; UA, Uric acid, μmol/L; RBP, Retinol-binding protein, mg/L; PLT, Platelet count, × 109/L; PDW, Platelet distribution width, %; PCT, Plateletcrit, ‱; MPV, Mean platelet volume, fL; RBC, Red blood cell, × 1012/L; HCT, Hematocrit, L/L; HGB, Hemoglobin, g/L; MCV, Mean corpuscular volume, fL; MCH, Mean corpuscular hemoglobin, pg; MCHC, Mean corpuscular hemoglobin concentration, g/L; RDW, Red blood cell distribution width, %; WBC, White blood cell, × 109/L; NE#, Neutrophil count, × 109/L; NE%, Neutrophil percentage, %; LY#, Lymphocyte count, × 109/L; LY%, Lymphocyte percentage, %; MO#, Monocyte count, × 109/L; MO%, Monocyte percentage, %; APTT, Activated partial thromboplastin time, s; TT, Thrombin time, s; PT, Prothrombin time, s; INR, International normalized ratio; FBG, Fibrinogen, g/L; Na, Sodium, mmol/L; K, Potassium, mmol/L; Cl, Chloride, mmol/L; Ca, Calcium, mg/dL; TG, Triglyceride, mmol/L; CHO, Cholesterol, mmol/L; HDL-C, High-density lipoprotein cholesterol, mmol/L; LDL-C, Low-density lipoprotein cholesterol, mmol/L; hsCRP, High-sensitivity C-reactive protein, mg/L; CK, Creatine kinase, U/L; CK-MB, Creatinine kinase-muscle/brain activity, U/L; LDH, Lactate dehydrogenase, U/L. COVID-19: coronavirus disease 2019.x¯: Average. M: Median. The bold fonts represent the median

*: Significant difference between the liver function damage group and the normal liver function group, P < 0.05