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. 2022 Mar 9;1203:339702. doi: 10.1016/j.aca.2022.339702

Fig. 4.

Fig. 4

On chip heating comparing cross-reactivity of SARS-CoV-2 nsp3 primer set against DENV3, MERS, and SARS inactivated virus. (A) Diffusion coefficient measurements indicate a significant difference between each off-target viruses and SARS-CoV-2 virus. Diffusion coefficients measurements trend toward lower values for the higher positive SARS-CoV-2 concentrations. While DENV3, MERS, and SARS were not statistically different from one another, significant differences were found for 5 × 101 (∗p < 0.05), 5 × 102 and 5 × 103 (∗∗∗∗p < 0.0001) SARS-CoV-2 viral particles per reaction concentrations compared to these off-target viruses via Tukey's multiple comparison test (N = 3). (B) 2% agarose gel confirmed PD results from samples extracted from each chip.