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. 2022 Mar 4;6:61–97. doi: 10.5414/ALX02303E

1. Nutrition. 1.3. Breast milk substitute and cow’s milk substitutes in children at risk.

Level of recommendation Statement
A/B Recommendation: If breastfeeding is not or not sufficiently possible, an infant formula should be given. For children at risk of allergies, it should be checked whether an infant formula with proven effectiveness, demonstrated in allergy prevention studies, is available until complementary food is introduced. (B)
Recommendation: Infant formula based on soy protein is not suitable for allergy prevention and should therefore not be given for this purpose. (A)
Comment: Soy products can be used as part of complementary foods, independently from the purpose of allergy prevention.
Recommendation: Since there is no proof of an allergy-preventive effect of other animal milk, such as goat milk (not even if they are the basis of infant formula), sheep or mare milk, these should also not be given for the purpose of allergy prevention. (B)
Comment: Cereal drinks are no milk substitute from a nutritional point of view.
Recommendation: Since there is no proof of an allergy-preventive effect of cereal drinks, these should also not be given for the purpose of allergy prevention. (B)
Level of evidence Hypoallergen (HA) hydrolyzed formula: Von Berg 2016 (1++), Davisse-Paturet 2019 (2++)
Soy formula: no current evidence found
Milks of other animals: no current evidence found
Level of consensus: Consensus