2. Food supplements. 2.3. Supplementation of other vitamins.

Level of recommendation	Statement
A	Background: There is insufficient proof that vitamin supplementation (such as A, C, E, K, or folic acid) during pregnancy is associated with prevention or an increased risk of atopic diseases in the child. There are no (reliable) study data on possible effects of vitamin supplementation in infancy.
	Recommendation: Pregnant women should not avoid taking folic acid for the purpose of allergy prevention. (A) Pregnant women and healthy infants or older children should not take vitamin supplements for allergy prevention. (A)
	Statement: Periconceptional folic acid supplementation according to the recommendations should be performed.
Level of evidence	Supplementation during pregnancy: Maslova 2014 (2++); Roy 2018 (2+); Trivedi 2018; den Dekker 2018 (2+); Crider 2013 (unrated)
	Supplementation in infancy: Aage 2015 (1++); Kiraly 2013a (1+); Kiraly 2013b (1+) [all without relevance for Germany]
Level of consensus:	Strong consensus