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. Author manuscript; available in PMC: 2022 Mar 9.
Published in final edited form as: J Control Release. 2021 Nov 18;341:206–214. doi: 10.1016/j.jconrel.2021.11.022

Figure 2. mRNA biodistribution does not indicate sites of mRNA translation.

Figure 2.

(A) To assess biodistribution, mice received IV injections of LNPs carrying Cy5-labeled mRNA at a dose of 0.75 mg/kg. LNPs predominantly distributed to the liver and to the spleen, lungs, and kidneys to a lesser extent. (B) Protein expression was determined by injecting mice via tail vein with LNPs carrying unmodified luciferase mRNA at a dose of 0.75 mg/kg. C12-200 and cKK-E12 facilitated protein expression almost entirely in the liver. 200Oi10 delivery resulted in a more diverse expression profile, as did ZA3-Ep10, with 70% of luciferase expression occurring in the lungs.