TABLE 1.
Coat protein complex | H. sapiens | S. cerevisiae | A. thaliana | Accessory Proteins | Known Cargo Motif | Pathway |
AP1 | γ1, 2 | γ1 | γ1, 2 | EPSIN, | ? | TGN/EE to PM |
β1, 2 | β1, 2 | β1, 2 | GGAs | ? | ||
μ1A, B | μ1 | μ1, 2 | YXXØ* | |||
σ1A, B, C | σ1 | σ1, 2 | [D/E]XXXL[L/I] | |||
| ||||||
AP2 | αA, C | α | α1, 2 | CALM, | ? | PM to TGN/EE |
β1, 2 | β1, 2 | β1, 2 | epsin, | ? | ||
μ2 | μ2 | μ2 | ARH, | YXXØ* | ||
σ2 | σ2 | σ2 | β-arrestin | [D/E]XXXL[L/I] | ||
| ||||||
AP3 | δ | δ | δ | ? | ? | EE to vacuole/lysosome, TGN/EE to vacuole/lysosome |
β3A, B | β3 | β3 | ? | |||
μ3A, B | μ3 | μ3 | YXXØ* | |||
σ3A, B | σ3 | σ3 | [D/E]XXXL[L/I] | |||
| ||||||
AP4 | ε | ε | ε | Tepsin, | ? | TGN to vacuole, TGN to specialized compartments |
β4 | β4 | β4 | MTV | ? | ||
μ4 | μ4 | μ4 | YXXØ* | |||
σ4 | σ4 | σ4 | [D/E]XXXL[L/I] | |||
| ||||||
AP5 | ζ | ζ | ζ | SPG11/15 | ? | late endosome to TGN, ? |
β5 | β5 | β5 | ||||
μ5 | μ5 | μ5 | ||||
σ5 | σ5 | / | ||||
| ||||||
TPC | / | / | TSPOON (LOLITA) | CALM, | ? | PM to TGN/EE |
/ | / | TSAUCER (TASH3) | Epsin, | |||
/ | / | TCUP (TML) | ARH, | |||
/ | / | TPLATE | β-arrestin | |||
/ | / | TTRAY1,TTRAY2 (TWD40-1, TWD40-2) | ||||
/ | / | AtEH1(Pan1), AtEH12(Pan1) | ||||
| ||||||
Retromer | VPS26 | Vps26p | VPS26A, VPS26B | SNX3, | ØX[L/M/V]; [ILMV]x[FY]xx2-13ØxØ or [FYW]x[FY]x3-15ØxØ; [-][-]x[-][ST]xØ | Vacuole/lysosome to Endosome, Endosome to Golgi/PM |
VPS29 | Vps29p | VPS29 | SNX27, | |||
VPS35 | Vps26p | VPS35B, VPS35C | WASH | |||
| ||||||
Retriever | VPS26c | / | VPS26C | SNX17, | NPxY/NxxY | |
VPS29 | / | VPS29 | CCC complex, | |||
VPS35L | / | VPS35A | WASH | |||
| ||||||
SNX-BAR | SNX1 | Vps5p | SNX1 | SNX5/6, | [ILMV]x[FY]xx2-13ØxØ or [FYW]x[FY]x3-15ØxØ; [-][-]x[-][ST]xØ | |
SNX2 | SNX2A,SNX2B | WASH |
*Ø represent hydrophobic amino acid, and X represent any amino acid.