Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 23;9:780200. doi: 10.3389/fmolb.2022.780200

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Wang, Lu, Zhang, Lin, Wu, Tang, Wu, Dou, Han, Wang, Hou, Ouyang, Feng, He and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Metformin enhanced the efficacy of PD-1 inhibitor in PBMCs-CDX mouse model. (A), Tumor growth curve of H460-derived xenograft mouse models treated as indicated. Tumor volume was shown as mean ± SEM (n = 5). *, p < 0.01 compared with the pembrolizumab group. (B), Macroscopic appearance of tumors after drug application for 4 weeks (C), Tumor weight (g) of each mouse was shown. *, p < 0.01. (D), The levels of serum AST, ALT, Urea and Creatinine in mice serum were presented as mean ± SEM (n = 5). (E), Immunohistochemistry analysis of CD8 in tumor sections from different groups. Representative images were shown. Scale bars: 200 μm. AST, Aspartate aminotransferase; ALT, Alanine aminotransferase; Crea, Creatinine.