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Angiogenic signaling pathway and key anti-angiogenic targets in tumor angiogenesis. VEGFR、PDGFR、FGFR、c-kit、c-Met involved in the key molecular signal events(RAS-RAF-MEK-ERK signaling pathway and PI3K-AKT-mTOR signaling pathway) which plays a significant role in tumor proliferation, migration and invasion. All approved angiogenic tyrosine kinase inhibitors (TKIs) can target multiple receptors simultaneously and inhibit the transduction of downstream signaling.
