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. 2022 Feb 23;10:814735. doi: 10.3389/fcell.2022.814735

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Copyright © 2022 Zhang, Liang, Feng, Liu, Wu, Tang, Liu, Lu, Wang and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of DEGs between the two clusters grouped by energy metabolism-related gene set and functional enrichment analysis. (A) Volcano plot of DEGs between two clusters with different metabolic statuses. The red and blue points represent up- and downregulated genes with statistical significance, respectively. (B) Heatmap of the top 50 up- and downregulated genes with the most differential changes. (C) GO/KEGG analysis of DEGs that were upregulated in cluster 1. (D) GO/KEGG analysis of DEGs that were downregulated in cluster 1. DEG: differentially expressed genes.