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. 2022 Feb 23;10:814735. doi: 10.3389/fcell.2022.814735

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Copyright © 2022 Zhang, Liang, Feng, Liu, Wu, Tang, Liu, Lu, Wang and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of immune cell infiltration between two clusters. (A) Immune cell score heatmap by xCell algorithm. Red represents high expression/score, whereas blue represents low expression/score. (B) Boxplot of immune infiltration status in two clusters by the CIBERSORT algorithm. Heatmap (C) and boxplot (D) of immune checkpoint-related gene expression between two clusters. Cancer stem cell scores (E) and chemotherapy resistance to doxorubicin (F) and gemcitabine (G) of the two clusters. *p < 0.05, **p < 0.01, ***p < 0.001.