Figure 7.

miR-10b-overexpressing CD4⁺ T cells promote inflammatory phenotypes of FLS and macrophages

(A) The sorting strategy of FLS and macrophages from RA synovium tissues. (B–F) The co-culture system experiments showed that miR-10b-overexpressing CD4⁺ T cells promote the proliferation, migration, and the release of inflammatory factors of FLS. (G–I) Co-culture experiments of CD4⁺ T cells and macrophages suggest that miR-10b knockdown CD4⁺ T cells could repress M1 polarization and MMPs of macrophages. Figures are presented as mean ± SD from at least three independent experiments. Rank-sum test; ∗p < 0.01 and ∗∗p < 0.01 versus control group.