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. 2021 Nov 1;35(15):1273–1290. doi: 10.1089/ars.2021.0052

FIG. 8.

FIG. 8.

Proposed approaches into effective bacterial clearance in the lungs after injury. (A) An FPR1 antagonist (CsH) reduces injury-enhanced secondary lung infection. The mtDAMPs were administered intraperitoneally to mice to mimic injury followed by intratracheal instillation of bacteria to mimic bacterial lung infection. Bacteria were counted in lung homogenates. Adapted from Itagaki et al. (51). (B) Airway PMN instillation clears bacteria in lungs after injury. In the experimental in vivo model described in (A), intratracheal administration of exogenous PMN into mouse lungs leads to bacteria clearance in lungs. Adapted from Zhang et al. (146). CsH, cyclosporin H.