Vaccine effectiveness (VE) of mRNA vaccines to prevent hospital admissions with covid-19 by variant group, including alpha, delta, and omicron. *Groups with ≥150 cases and controls were reported. Groups with <150 cases or <150 controls were not reported owing to low precision of VE estimates with these sample sizes. †Obtained using structured medical chart review, and defined as one or more of the following: active solid organ cancer (active cancer defined as treatment for the cancer or newly diagnosed cancer in past six months), active hematologic cancer, HIV infection without AIDS, AIDS, congenital immunodeficiency syndrome, previous splenectomy, previous solid organ transplant, immunosuppressive drugs, systemic lupus erythematosus, rheumatoid arthritis, psoriasis, scleroderma, or inflammatory bowel disease, including Crohn’s disease or ulcerative colitis. ‡Obtained using structured medical chart review, and defined as conditions within one or more of the following categories: cardiovascular disease, neurologic disease, pulmonary disease, gastrointestinal disease, endocrine disease, renal disease, hematologic disease, malignancy, immunosuppression not captured in other categories, autoimmune condition, or other condition (sarcoidosis, amyloidosis, or unintentional weight loss ≥10 pounds (4.5 kg) in past 90 days)