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. 2022 Feb 23;13:843829. doi: 10.3389/fphar.2022.843829

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Copyright © 2022 Dong, Zhang, Cai, Teng, Wang, Fu, Cui, Patel, Wang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of ARS-1620 on the ATPase activity of ABCB1 and ARS-1620 got actively transported out by ABCB1-overexpressing cancer cells. (A) ARS-1620 (0–160 μM) stimulates ABCB1 ATPase activity. (B) The intracellular accumulation of ARS-1620 in KB-3-1 and KB-C2 cells. Data are displayed as mean ± SD of three independent assays. *p < 0.05.