Table 4.

Follow-up of asymptomatic SDHx mutation carriers

Follow-up of asymptomatic SDHx mutation carriers	Adults	Children
Initial screening	Clinical examination (including bp), biochemical testing, MRI (base of the skull to pelvis), [68Ga]-DOTA-SSA PET/CT	Clinical examination (including bp), biochemical testing, MRI (base of the skull to pelvis) (initiation: at the age of 6-10 and 10-15 years for SDHB and SDHA/C/D mutation carriers, respectively)
Follow-up	Every 12 months clinical examination (including bp) & biochemical testing (plasma > urine), every 24-36 months MRI (base of the skull to pelvis) (no consensus on alternating MRI and PET/CT)	Every 12 months clinical examination (including bp), every 24 months biochemical testing, every 24-36 months MRI (base of the skull to pelvis)

Abbreviations: bp, blood pressure; MRI, magnetic resonance imaging; PET/CT, positron emission tomography/computed tomography.