Practical tip/synthesis:
• Figure 6 summarizes the Wnt signaling-associated cluster 3 with its gain-of-function mutations/events. • Cluster 3 comprises the MAML3 fusion gene and somatic mutations in CSDE1 associated with overactivation of Wnt- and ß-catenin signaling leading, among others, to angiogenesis, proliferation, survival, invasion, metastasis, and deregulation of metabolism.