Personalized Management of Pheochromocytoma and Paraganglioma

. 2021 Jun 19;43(2):199–239. doi: 10.1210/endrev/bnab019

Practical tip/synthesis (applies to all clusters):
• Whenever possible, surgery is the therapy of choice. • Details in terms of surgery, surgery in (oligo-)metastatic disease and alpha-adrenoceptor blockade are described in “Treatment” under “Personalized Management: Molecular Cluster 1.” • Figure 4 summarizes a therapy flow-chart which suggests a potential sequence of therapy for a practicing physician, including dosing. • All suggestions in terms of therapy and sequence of therapy are described in detail in “Treatment” under “Personalized Management: Molecular Cluster 1” and apply to all clusters. • Future systemic therapy approaches that might be specifically effective in Wnt signaling cluster 3-related PCCs are specific inhibitors of Wnt signaling (Fig. 6).

Practical tip/synthesis (applies to all clusters):

• Whenever possible, surgery is the therapy of choice.
• Details in terms of surgery, surgery in (oligo-)metastatic disease and alpha-adrenoceptor blockade are described in “Treatment” under “Personalized Management: Molecular Cluster 1.”
• Figure 4 summarizes a therapy flow-chart which suggests a potential sequence of therapy for a practicing physician, including dosing.
• All suggestions in terms of therapy and sequence of therapy are described in detail in “Treatment” under “Personalized Management: Molecular Cluster 1” and apply to all clusters.
• Future systemic therapy approaches that might be specifically effective in Wnt signaling cluster 3-related PCCs are specific inhibitors of Wnt signaling (Fig. 6).