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. 2022 Feb 23;13:783506. doi: 10.3389/fphar.2022.783506

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Copyright © 2022 Ma, Lv, Yu, Jia, Song, Xu, Li, Sheng, Wang, Zhang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of bilobalide on the IL-1β-induced inflammatory reaction in ATDC5 chondrocytes. (A,B) Western blot analysis of iNOS, COX-2, and MMP13 protein levels in chondrocytes. All data were presented as mean ± SD (n = 3). *p < .05 and **p < .01 compared to the control group; ^# p < .05 and ^## p < .01 compared to the IL-1β group (Statistical analysis using one-way ANOVA and paired two-tailed Student’s t-test).