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. 2022 Feb 23;13:839640. doi: 10.3389/fphar.2022.839640

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Copyright © 2022 Wang, Wang, Liu, Jiang, Cai, Li and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of canagliflozin (Cana) on lipid profile in type 2 diabetes mellitus (T2DM) mice. Triglyceride (TG) (A), total cholesterol (TC) (B), low-density lipoprotein cholesterol (LDL-C) (C), and high-density lipoprotein cholesterol (HDL-C) (D) levels in serum. Atherogenic index of plasma (AIP) (E), calculated by lg(TG / HDL-C). Atherogenic index (AI) (F), calculated by (TC − HDL-C) / HDL-C. Cardiac tissues with Oil Red O staining (G). Data are expressed as mean ± SEM. ^& p < 0.05, the Cana group compared with the Metf group; ^# p < 0.05, compared with the model group; *p < 0.05, compared with the control group. Six mice in each group were randomly selected, and statistical analyses were performed.