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. 2022 Feb 23;13:839640. doi: 10.3389/fphar.2022.839640

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Copyright © 2022 Wang, Wang, Liu, Jiang, Cai, Li and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Cana on alleviating oxidative stress and relieving inflammation. Reactive oxygen species (ROS) in cardiac tissues (A). Superoxide dismutase (SOD) (B), gluthathione (GSH) (C), and malondialdehyde (MDA) (D) contents in cardiac tissues. The regulatory effect of Cana on cardiac mitochondria in myocardial tissues (E). The scale bar is 5 and 1 μm in the upper panel and bottom panel, respectively. Serum concentrations of tumor necrosis factor (TNF)-alpha (F), monocyte chemotactic protein 1 (MCP-1) (G), and interleukin 6 (IL-6) (H). The immunofluorescence staining of heme oxygenase 1 (HO-1) in cardiac tissues, scale bar: 50 μm (I). Data are expressed as mean ± SEM. #p < 0.05, compared with the model group; *p < 0.05, compared with the control group. Six mice in each group were randomly selected for analyses.