Figure 2.

Association of HER2 alterations with tumor features. (A, B) Association of HER2 mutation with HER2 protein expression, microsatellite instability (MSI), tumor mutation burden (TMB), tumor neoantigen burden (TNB) (A), and selected infiltrating immune cells whose aundances were calculated based on transcriptome data and downloaded from the immune landscape of TCGA (B). (C, D) The same analysis items as in A for HER2 amplification. RPPA, reverse-phase protein array; Mut, mutation; WT, wild-type; AMPL, amplification; Norm, normal; TME, tumor microenvironment; Tregs, regulatory T cells; TCGA, The Cancer Genome Atlas.