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. 2022 Feb 23;13:799988. doi: 10.3389/fimmu.2022.799988

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Copyright © 2022 Wang, Chen, Du, Li, Ying, Lu, Shen, Gao, Yi, Xia, Sui and Shu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association of HER2 mutation with tumor features validated in independent stomach adenocarcinoma (STAD) cohorts. (A) Incidences of HER2 alterations in ACRG and AHJU. (B) Association of HER2 mutation with microsatellite instability (MSI), tumor mutation burden (TMB), and tumor neoantigen burden (TNB). (C) Multiple-immunofluorescence staining of surface biomarkers of immune cells in STAD tissues. 1: CD8 staining; 2: CD56 staining; 3: CD68 (green) and HLA-DR (red) staining; 4: the reconstructed image for all surface biomarkers. (D) The density of infiltrating immune cells in tumor parenchyma stratified by HER2 mutation status. ACRG, Asian Cancer Research Group; AHJU, Affiliated Hospital of Jiangsu University; AMPL, amplification; Mut, mutation; WT, wild-type.