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. 2022 Feb 23;13:799988. doi: 10.3389/fimmu.2022.799988

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Copyright © 2022 Wang, Chen, Du, Li, Ying, Lu, Shen, Gao, Yi, Xia, Sui and Shu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome features associated with HER2 mutation. (A) A clustered heat map for top 40 genes differentially expressed between HER2 mutation (Mut) and wild-type (WT) subgroups in ACRG. (B) Selected enriched signaling pathways based on Kyoto Encyclopedia of Genes and Genomes (KEGG) and biological process (BP) terms of Gene Ontology (GO) in gene set enrichment analysis (GSEA). (C) Enrichment plots for selected immune-associated signaling or functions. (D) Tumor proliferation and interferon-gamma response scores according to HER2 mutation status in the TCGA Pan-Cancer cohort. ACRG, Asian Cancer Research Group; TCGA, The Cancer Genome Atlas.