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Schematic representation of the production and function of SARS- CoV- 2 PLpro. The positive- strand RNA (numbers indicate nucleotide position) including the ORF 1a/b, structural proteins S (spike), E (envelope), M (membrane) and N (nucleocapsid) are shown. PLpro is encoded by part of nsp3. It is able to mature nsp1- 3 and preferentially cleave the ubiquitin- like protein ISG15 from IRF3 by recognizing specific cleavage sites.
