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. 2022 Feb 23;10:822785. doi: 10.3389/fchem.2022.822785

FIGURE 2.

FIGURE 2

Crystal structures of SARS-CoV-2 PLpro in apo and substrate-bound forms. (A) Crystal structure of SARS-CoV-2 PLpro (PDB ID: 6WZU). The four distinct subdomains are indicated. The catalytic triad is shown in the blue dashed circle. (B) Superposition of ubiquitin/PLpro complex (PDB ID: 6XAA) with mouse-ISG15/PLpro complex (PDB ID: 6YVA). The catalytic triad is shown in the blue dashed circle. The two ubiquitin binding sites are indicated. The ubiquitin is colored in cyan, while the mouse ISG15 is colored in orange.