Fig. 11. Photoswitching of NMDARs using genetic-code expansion. (a) Structure of NMDARs composed of GluN1 and GluN2 subunits. In the right panel, the top view of the LBD is shown, and mutation site (P523) is highlighted. (b) Structure of the transmembrane domain (TMD) of NMDARs represented by a side (Left) and top view (Right). (c) Representative current traces of NMDARs having an azobenzene-based photo-responsive UAA (PSAA) at P532 in the LBD (in left) or at F654 in the TMD (in right). Reproduced with permission from ref. 147. Copyright 2017 by eLife Sciences Publications, Ltd.