Fig. 2. Schematic illustration of PSAM/PSEM system. (a) By combining different IPDs for a given PSAM/PSEM pair, multiple functional outcomes can be achieved, including neuronal activation, regulation of calcium flux, and neuronal silencing. Development of multiple orthogonal PSAM/PSEM pairs has enabled the combinatorial generation of diverse chemogenic ion channel tools. (b) Chemical structures of varenicline and uPSEMs.
