Fig. 6. Application of light-induced dimerization or oligomerization to membrane receptors. (a) Representative systems of light-inducible dimerization or oligomerization. (b) Expansion of wavelength available for photoactivate proteins. Three black bars correspond the wavelength covered by each chromophore. (c) Regulation of RTK with light. Intracellular region of RTK is fused with PHR domain of CRY2, which homodimerizes upon photo-irradiation. TKD, Tyrosine kinase domain. (d) Photo-Induced interaction between β2AR and β-arrestin utilizing CRY2-CIB interaction.
