Fig. 8. Optical control of a PORTL (BGAG12)-tethered mGlu2 (SNAG-mGlu2). (a) Schematic illustration of PORTL-mediated reversible regulation of SNAG-mGlu2 (top). Chemical structure of the PORTL, BGAG12 (bottom). (b) Schematic illustration of branched BGAG12-tethered mGlu2 (left). Bar plot showing photoswitch efficiencies for different levels of branched BGAG12-tethered mGlu2 (right). Reproduced with permission from ref. 130. Copyright 2020 by Elsevier, Inc. (c) Chemical structure of an optimized PORTL with 4-urea-4′-amide azobenzene, BGAG12,400.
