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. 2022 Feb 23;14:795764. doi: 10.3389/fnagi.2022.795764

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Copyright © 2022 Solé-Padullés, Macià, Andersson, Stiernstedt, Pudas, Düzel, Zsoldos, Ebmeier, Binnewies, Drevon, Brandmaier, Mowinckel, Fjell, Madsen, Baaré, Lindenberger, Nyberg, Walhovd and Bartrés-Faz.

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Hippocampal (HPC) volume predicted trajectories versus age after 60 for different loneliness levels for BETULA (A) and BASE-II (B). (C) Depicts hippocampal trajectories for the younger participants (HUBU cohort) from age 10 onwards, as regards the loneliness variable. Raw hippocampal volumes are shown for HUBU, as absolute values might be more convenient in longitudinal studies of brain development (Goddings et al., 2014). Dotted lines show 95% confidence interval for predictions with random effects set to 0.