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. 2022 Feb 23;9:837143. doi: 10.3389/fmed.2022.837143

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Copyright © 2022 Zhang, Huang, Cai, Zhao, Xiao, Quan, Tang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of differentially expressed genes (DEGs). (A) Four datasets (GSE8671, GSE32323, GSE24514, GSE14333) were retrieved from the GEO database to identify the shared DEGs in CRC. Eventually, a total of 62 shared DEGs were identified using GEO2R; (B) TKT was significantly and highly expressed in CRC tissues compared to normal colon tissues in the GEPIA database; (C) High TKT expression in CRC was associated with poor 5-year survival in the GEPIA database. ^*P <0.05 vs. normal colon tissues.