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. 2022 Feb 23;9:837143. doi: 10.3389/fmed.2022.837143

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Copyright © 2022 Zhang, Huang, Cai, Zhao, Xiao, Quan, Tang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of TKT suppresses cell migration. (A,B) HCT116 cells were treated with DMSO or the TKT inhibitor N3PT (5 μM or 10 μM), and cell migration was assayed by wound healing assay (A) or Transwell assay (B). The wound-healing assays showed no significant difference in the migration rate among the 5 μM N3PT, 10 μM N3PT and control groups. However, the migration rate was significantly decreased in the 5 μM N3PT and 10 μM N3PT groups in a Transwell assay. (C,D) HCT116 cells were transfected with TKT siRNA or negative control (NC siRNA), and cell migration was assayed by wound healing assay (C) or Transwell assay (D). TKT siRNA transfected cells presented a significantly lower wound healing rate (C) and migration ability (D) than the NC siRNA-transfected cells. N = 3/group, *P <0.05, **P <0.01, ***P <0.001 vs. the control group.