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. 2022 Mar 9;2022(3):CD015125. doi: 10.1002/14651858.CD015125

Risk of bias for analysis 1.4 Symptom resolution: mean time to recovery (days).

Study Bias
Randomisation process Deviations from intended interventions Missing outcome data Measurement of the outcome Selection of the reported results Overall
Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement
Ramakrishnan 2021 Low risk of bias Stratified block randomisation, sequence held in secure network location at Oxford University, characteristics incl. SARS‐CoV‐2 status are well balanced. Low risk of bias We judged this domain low due to only a low number of participants withdrew consent Low risk of bias We judged this domain low due to no evidence of relevant missing data. In the intervention group about 1% and in the control group about 4% of the participants withdrew consent due to the allocation. High risk of bias We judged this domain high due to the unanswered question when are the participants considered recovered and the outcome is very subjective. Some concerns We judged this domain some concerns because the outcome was not pre‐specified. High risk of bias Overall judged high risk of bias due to the unanswered question when are the participants considered recovered and the subjective perspective of the outcome.