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. 2022 Mar 9;2022(3):CD015125. doi: 10.1002/14651858.CD015125

Risk of bias for analysis 1.7 Serious adverse events.

Study Bias
Randomisation process Deviations from intended interventions Missing outcome data Measurement of the outcome Selection of the reported results Overall
Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement
Yu 2021 Low risk of bias Participants were randomised via web‐based Sortition and the allocation sequence was intimated to GP and patient via email/letter. There are no baseline differences that would suggest a problem with randomisation Low risk of bias We judged risk of bias low because there were no reported deviations from intended interventions. Low risk of bias We judged this domain low because it is not likely that missingness in the outcome depended on its true value. There were about 5% of the participants without a diary entry. High risk of bias We judged this domain high because it is likely that the knowledge of the intervention has influenced the subjective self‐assessment of this outcome. Low risk of bias The data were in accordance with the protocol, so that we assessed domain 5 low. High risk of bias Overall judged high risk of bias due to measurement of the outcome.