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C. neoformans cells grown in the presence of subinhibitory concentrations of AmB or FLU vary morphologically. Encapsulated cryptococcal cells of strain ATCC 24076 grown in medium with 0.5 the MIC of AmB can appear normal (A) or have shed part or all of their capsules (B and C, respectively). Acapsular strain CAP67 typically appears in the shape of a lemon (D) but more commonly appears round when it is grown with 0.5 the MIC of AmB or FLU (E). Magnifications, ×2,000.
