TABLE 2.

Scanning electron microscopy of C. neoformans with and without exposure to AmB or FLU

Strain	Druga	SAB		10% FCS
		No. of atypical cells/total no. of cellsb	P valuec	No. of atypical cells/total no. of cellsb	P valuec
ATCC 24067	⊘	12/80
	FLU	34/80	<0.001
	AmB	47/80	<0.001
ATCC 3501	⊘	10/80		7/40
	FLU	26/80	0.005	17/40	0.026
	AmB	40/80	<0.001	23/40	<0.001
CAP67	⊘	18/80		24/40
	FLU	53/80	<0.001	38/40	<0.001
	AmB	57/80	<0.001	40/40	<0.001

^aAbsence of drug (⊘) or either AmB or FLU at concentrations of 0.5 the MIC for the individual strain is indicated. 

^bThe ratio represents the number of atypical cells relative to the total number of cells counted by scanning electron microscopy. For ATCC 24067 and ATCC 3501, this describes the number of cells with aberrant or absent capsules versus the total number counted. For CAP67, this represents the number of round cells compared to the total number of cells evaluated. 

^cP values were calculated by the chi-square test by using the results of an analysis of a drug-treated strain relative to the results of an analysis of the same strain without drug exposure.