. 1999 Feb;43(2):233–239. doi: 10.1128/aac.43.2.233

TABLE 4.

Cell measurements for strains ATCC 24067 and ATCC 3501 with and without AmB and FLU

Strain	Drug^a	Cell size^b	P value^c	Capsule size^d	P value	Capsule size/total size^e	P value
ATCC 24067	⊘	5.67 ± 0.73		1.57 ± 0.59		0.21 ± 0.05
	FLU	4.95 ± 1.11	0.020	0.91 ± 0.32	<0.001	0.15 ± 0.04	<0.001
	AmB	4.75 ± 0.79	<0.001	0.86 ± 0.34	<0.001	0.14 ± 0.04	<0.001
ATCC 3501	⊘	7.25 ± 1.67		1.85 ± 0.67		0.20 ± 0.04
	FLU	5.97 ± 1.07	0.007	0.96 ± 0.40	<0.001	0.13 ± 0.03	<0.001
	AmB	5.15 ± 1.18	<0.001	0.80 ± 0.36	<0.001	0.13 ± 0.04	<0.001

Absence of antibiotics (⊘) or presence of either AmB or FLU at 0.5 the MIC for the cryptococcal strain is indicated.

Cell size is measured (n = 20) as the size of the cell body exclusive of the polysaccharide capsule.

P values were determined by Student’s t test by using values for a drug-treated strain compared to those for the same strain without drug exposure.

Capsule size is the distance from the cell wall to the outer capsular border.

Normalized values were determined by dividing each individual measurement of capsule size by the size of the entire organism (cell diameter inclusive of the polysaccharide capsule).