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. 2022 Feb 23;13:827523. doi: 10.3389/fendo.2022.827523

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Copyright © 2022 Zhou, Xu, Wang, Ling, Nong, Xie, Zhu and Shan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The changes of transcriptome profile in porcine SAT after cold exposure. (A) Volcano plot of differently expressed genes (DEGs). Log2 fold changes in exons of RNA-seq gene bodies in COLD versus RT pigs and the corresponding significance values displayed as log10 (P value). In total, 536 and 621 genes were identified that had induced (red) or repressed (blue) expression levels by cold exposure, gray denotes genes with no significant changes. (B) Gene Ontology (GO) enrichment analysis. (C) Functional enrichment analyses using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. (D, E) Heatmaps of the TPM expression values of selected thermogenesis, fatty acid metabolism regulated genes from the RNA-seq dataset. (F–H) KEGG results of the cold-induced enrichment of genes involved in adipocytokine signaling pathway (F), apoptosis (G), PI3K-Akt signaling pathway (H).