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. Author manuscript; available in PMC: 2022 Mar 9.
Published in final edited form as: Vaccine. 2020 Feb 3;38(10):2307–2314. doi: 10.1016/j.vaccine.2020.01.068

Figure 5: Guinea Pig Immune Response against Anthrax: TNA ED50 (A), TNA NF50 (B), and anti-PA IgG (C) Group Geometric Means with 95 Percent Confidence Intervals by Study Day.

Figure 5:

Animals were vaccinated 1 and 8 days post-challenge with serial dilutions of AV7909 (Groups 1–5), a 1:16 dilution of AVA (Group 6), or 0.5 mL of normal saline (Group 7). Group 8 served as a positive control for lethal exposures to B. anthracis and were neither vaccinated nor treated with ciprofloxacin. Immune response analyses were performed as described previously [22, 23]. All animals in the control group (Group 8) died prior to Study Day 8; therefore, Group 8 was not included in the ANOVA models fitted on the post-challenge study days.