Table 2.

SCI definitions

SCI feature	SCI definition	SCI assigned score
Composite cardiac disease/dysfunction	Coronary artery disease, congestive heart failure, history of myocardial infarction, or left ventricular ejection fraction ≤ 50% OR atrial fibrillation or flutter, sick sinus syndrome, or ventricular arrhythmias OR valvular heart disease (except mitral valve prolapse)	1
Moderate pulmonary dysfunction	DLCo* or FEV1 66-80% or dyspnea on slight activity	1
Age ≥ 60 y		1
Severe pulmonary dysfunction	DLCo* or FEV1 < 66 or dyspnea at rest/oxygen dependent	2
Moderate to severe hepatic dysfunction	Serum bilirubin > 1.5 times ULN; ALT or AST > 2.5 times ULN, or chronic hepatitis	2
Mild renal dysfunction	eGFR† between 60 and 89.9 mL/min per 1.73 m2	2
Moderate to severe renal dysfunction	eGFR < 60 mL/min per 1.73 m2	3

ALT, alanine aminotransferase; AST, aspartate aminotransferase; DLCo, diffusion capacity of the lung for CO; FEV₁, forced expiratory volume in 1 second; ULN, upper limit of normal.

^*DLCo was corrected for hemoglobin using the formula of Cotes et al.⁴⁹

^†eGFR was calculated using the CKD-EPI equation of Levey et al.³⁴