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. 2022 Mar 4;6(5):1547–1558. doi: 10.1182/bloodadvances.2021005941

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Figure 2. — Bone marrow immunophenotyping after ASCT and mRNA-electroporated LC vaccines. BMMCs were analyzed by flow cytometry to profile the lymphocyte composition postvaccination in comparison with baseline (prevaccine) and an unvaccinated control cohort. (A) t-Distributed stochastic neighbor embedding plots at 3 months after vaccination showing CD4 and CD8 T cells (far left plot), CD4 and CD8 effector memory cells (T_EM; CCR7^negCD45RA^neg) (middle left plot), CD4 and CD8 naive cells (T_N; CCR7⁺CD45RO^neg) (middle right plot), and PD-1–expressing CD4 and CD8 cells (far right plot). CD4 (B) and CD8 (C) effector memory, naive, and PD-1–expressing cells at 1 and 3 months after vaccines. Pooled data (mean ± standard deviation) are shown for patients in the control (red circles) and vaccine (blue squares) arms. ns, not significant; Pre, prevaccine.